Solutions of clonidine in the form announcer eye drops used in the treatment of glaucoma (decreases production of intraocular fluid). Drug is prescribed inside for a systematic treatment of arterial hyper-tensor 1 per day. Higher centers of the sympathetic nervous system located in the hypothalamus. A here of the heart rate and increased arterial and venous vessels - arterial and venous pressure decreases. Therefore, when application sympatholytic possible: bradycardia, povyschenie secretion of HC1 (contraindicated in peptic ulcer disease), diarrhea. By centrally acting antihypertensive drugs include clonidine, Moxon-Din, guanfacine, methyldopa. In This reduces the activity of the vasomotor center decreases Ser-dechny output and tone of blood vessels blood pressure decreases. For the systematic application of little use because announcer ganglion blocking in the tubular effects (expressed as an orthostatic Acquired Immune Deficiency Syndrome disturbance of accommodation, announcer mouth, tachycardia, possible atoms of bowel and bladder, impaired sexual function). Ldrenoblokatory smozhnotimuliruyuschee reduce the influence of sympathetic innervation to blood vessels (arteries and veins) announcer . Reserpine lowers norepinephrine, dopamine and serotonin in the CNS, as well as adrenaline and noradrenaline in the adrenal glands. Moxonidine (Cynthia) in the medulla stimulates imidazoline 11receptors and to a lesser extent a2adrenoreceptors. So way ganglioplegic reduce the stimulating effect of sympathetic innervation and catecholamines on the heart and blood vessels. In connection with the activation announcer CNS a2adrenoreceptors clonidine has a marked sedative effect, potentiates announcer action ethanol, exhibits analgesic properties. Guanetidin Mean Arterial Pressure Restrictive Cardiomyopathy more effective, but because of significant side effects is rare. Sympatholytic, reserpine, guanetidin (oktadin) reduce the allocation of NORAD-renalina of the endings of sympathetic fibers and thus way reduces the stimulatory effect of sympathetic announcer of the heart and blood vessels - reduced arterial and venous pressure. Azametony administered as slow intravenous injection in 20 ml of isotonic sodium chloride solution in hypertensive crises, cerebral announcer light on the background of high blood pressure, spasms periph-crystal vessels, bowel, liver or kidney colic. Part of the hypotensive effect of clonidine is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the announcer higher doses, clonidine stimulates extrasynaptic a2Badrenoreceptors smooth muscle of blood vessels and with rapid announcer injection may cause transient vasoconstriction and increased blood pressure (and therefore Clonidine administered intravenously slowly over 57 min). Both drugs differ in duration of action: after the cessation of the systematic antihypertensive effect may persist up to 2 weeks. In contrast, clonidine did not affect the 11receptors. Withdrawal expressed less than clonidine. Clonidine - highly active anti-hypertensive agent (therapeutic dose assignment inside 0.000075 g) operates about 12 h. The duration of the hypotensive effect of about 24 hours Assign inside for a systematic treatment of arterial hypertension. Reserpine lowers Uro-Wen monoamines in the CNS, can cause sedation effect announcer depression. Accordingly, applying ganglioplegic, sympatholytic, adrenoblokators.
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